Periodontitis Research Today is a free monthly online journal that collates and summarizes the latest research about Periodontitis, including details on treatment, causes, gingivitis, symptoms.

Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis.

Park YJ, Lee JY, Yeom HR, Kim KH, Lee SC, Shim IK, Chung CP, Lee SJ

Craniomaxillofacial Reconstructive Science Major, Dental Research Institute, College of Dentistry, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, 110-749, Seoul, Korea.

Injectable polysaccharide microcapsules holding minocycline were fabricated from alginate and chitosan for the treatment of periodontitis. The microcapsules were examined for the release and degradation of minocycline, as well as antimicrobial activity. The microcapsules were biodegradable and released minocycline between 10 and 1000 microg ml(-1), which was higher than the usual therapeutic concentration (1-5 microg ml(-1)), for up to 7 days. These microcapsules showed a statistically significant suppression of pathogenic bacteria, such as Prevotella intermedia causing periodontitis. The microcapsules are thus potentially useful for drug delivery for the treatment of periodontitis.

Published 29 November 2005 in Biotechnol Lett, 27(22): 1761-6.
Full-text of this article is available online (may require subscription).

© 2005-2008 Periodontitis Research Today. All Rights Reserved.